Is (+)-[ 13 C]-pantoprazole better than (±)-[ 13 C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?
نویسندگان
چکیده
منابع مشابه
Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.
We tested the hypothesis that the stable isotope [(13)C]pantoprazole is O-demethylated by cytochrome P450 CYP2C19 and that the (13)CO(2) produced and exhaled in breath as a result can serve as a safe, rapid, and noninvasive phenotyping marker of CYP2C19 activity in vivo. Healthy volunteers who had been genotyped for the CYP2C19(*)2, CYP2C19(*)3, and CYP2C19(*)17 alleles were administered a sing...
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Where tanh is the hyperbolic tangens function, h the Planck constant, BBo is the main magnetic field strength, kBB the Boltzmann constant and T is the temperature. At a magnetic field of 1.5 T the polarization of the protons (H) at body temperature is only ∼5 x 10 and for C ∼1.0 x 10. The polarization is proportional to the magnetic field strength. Consequently, a 3 T scanner will result in a d...
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The phenotype pantoprazole-(13)C breath test (Ptz-BT) was used to evaluate the extent of phenoconversion of CYP2C19 enzyme activity caused by commonly prescribed proton pump inhibitors (PPI) omeprazole and esomprazole. The Ptz-BT was administered to 26 healthy volunteers and 8 stable cardiovascular patients twice at baseline and after 28 days of PPI therapy to evaluate reproducibility of the Pt...
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ژورنال
عنوان ژورنال: Journal of Breath Research
سال: 2012
ISSN: 1752-7155,1752-7163
DOI: 10.1088/1752-7155/7/1/016001